Clinical guidelines, IFUs, and key references.
The rule engine and sizing matrices in TAVI Copilot are built directly from these sources. Links open externally — always verify against the active local IFU before clinical action.
ESC/EACTS Guidelines 2025
Management of Valvular Heart Disease
European Society of Cardiology / European Association for Cardio-Thoracic Surgery joint guidelines on valvular heart disease management, including TAVI indications and recommendations.
ACC/AHA Guideline 2020
Valvular Heart Disease: A Report of the ACC/AHA Joint Committee
American College of Cardiology / American Heart Association guideline for the management of patients with valvular heart disease. Section 3.2.4 covers aortic valve intervention.
Edwards SAPIEN 3 / SAPIEN 3 Ultra IFU
Transcatheter Heart Valve System
Instructions for Use for the balloon-expandable SAPIEN 3 and SAPIEN 3 Ultra valve systems, including sizing matrix and anatomical suitability criteria.
Medtronic Evolut PRO+ / FX IFU
Self-Expanding Transcatheter Aortic Valve System
Instructions for Use for the self-expanding Evolut PRO+ and Evolut FX transcatheter aortic valve systems, with annular sizing and anatomical requirements.
Meril Myval / Myval Octacor IFU
Balloon-Expandable Transcatheter Heart Valve
Instructions for Use for the Meril Myval and Myval Octacor balloon-expandable THV, including the intermediate-size (21.5/24.5/27.5/30.5 mm) and XL (32 mm) matrix.
Abbott Navitor IFU
Transcatheter Aortic Valve Implant System
Instructions for Use for the Navitor transcatheter aortic valve implant system.
SMART Trial — SAPIEN 3 / SAPIEN 3 Ultra in Small Aortic Annulus
NCT04722250
Randomized controlled trial comparing TAVI with SAVR in patients with severe aortic stenosis and small aortic annulus (≤ 23 mm). Primary results published in The Lancet 2023.
VIVA Trial — SAPIEN 3 Ultra
NCT04153292
Clinical trial evaluating the SAPIEN 3 Ultra transcatheter heart valve system in low-risk aortic stenosis patients.
Evolut Low Risk Trial
NCT02701283
Pivotal trial comparing TAVI with SAVR in patients with severe aortic stenosis at low surgical risk.
EuroSCORE II Calculator
European System for Cardiac Operative Risk Evaluation
Online calculator for predicting operative mortality in adult cardiac surgery.
STS Adult Cardiac Surgery Risk Calculator
Society of Thoracic Surgeons
Online risk calculator for estimating the risk of operative mortality and morbidity in adult cardiac surgery.
Disclaimer
This page provides external links to clinical guidelines, manufacturer IFUs, and publications for reference purposes only. TAVI Copilot is a research and educational prototype — not a medical device. Always confirm every recommendation against the active local IFU and Heart Team judgment before clinical action. We do not control the content of external sites and are not responsible for their accuracy or availability.